Predicted mutation | ||||||
---|---|---|---|---|---|---|
evidence | seq id | position | mutation | annotation | gene | description |
JC JC | NC_000913 | 1,293,032 | IS1 (–) +8 bp | intergenic (‑110/‑488) | hns ← / → tdk | global DNA‑binding transcriptional dual regulator H‑NS/thymidine kinase/deoxyuridine kinase |
New junction evidence | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
seq id | position | reads (cov) | reads (cov) | score | skew | freq | annotation | gene | product | ||
* | ? | NC_000913 | 257908 = | NA (NA) | 26 (0.900) | 23/284 | 0.3 | 100% | noncoding (768/768 nt) | IS1 | repeat region |
? | NC_000913 | = 1293039 | 0 (0.000) | intergenic (‑117/‑488) | hns/tdk | global DNA‑binding transcriptional dual regulator H‑NS/thymidine kinase/deoxyuridine kinase | |||||
* | ? | NC_000913 | 1293032 = | 0 (0.000) | 41 (1.430) | 35/284 | 0.0 | 100% | intergenic (‑110/‑495) | hns/tdk | global DNA‑binding transcriptional dual regulator H‑NS/thymidine kinase/deoxyuridine kinase |
? | NC_000913 | = 1979270 | NA (NA) | noncoding (1/768 nt) | IS1 | repeat region |
ATGTTGTTCAGAATTTTAAGTGCTTCGCTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTATGGGGAGATTATCGTAGG > NC_000913/1292891‑1293171 | cgctgatgtccggcggtgcttttgccgttacgcaccaccccgtcagtagctgaacaggagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcacctt < 1:340835‑M1/2‑1 (MQ=255) cgctgatgtccggcggtgcttttgccgttacgcaccaccccgtcagtagctgaacaggagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaaattggcagcatcacctt < 2:526040‑M1/2‑1 (MQ=255) tgttgtTCAGAATTTTAAGTGCTTCGCTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTGGTGCAATAGCCGGGAATGTAAGGAATTAAAAATTGTTCTTTAtttca > 2:58805/1‑141 (MQ=255) atgtgcggccgtgcttttgccgttacgcaccacctcgtcagtagctgaacaggagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtatgttggcagcatcaccttgtgtc > 2:288595‑M1/137‑141 (MQ=255) ttCAGAATTTTAAGTGCTTCGCTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTACATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCGAAATTGTTCTTTATTTTGTgccg > 2:397334/1‑143 (MQ=255) ttAAGTGCTTCGCTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgac < 1:290363‑M2/143‑10 (MQ=255) ttttgccgttacgcaccaccccgtcagtagctgaacaagacggacagctgctagaaacagaagcccctggagcacctcaaaaacaccatcatacactaaatcagtaagctaacagcataaccTTGTACCgccaataaataact < 2:136342‑M1/21‑4 (MQ=255) ttgcctttacgcaccaccccgtcagtagctgaacaggagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCttt > 1:483195‑M1/121‑143 (MQ=255) gCTTCGCTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaac < 2:97340‑M2/143‑16 (MQ=255) cTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattg < 2:144216‑M2/143‑22 (MQ=255) gcaccaccccgtcagtagctgaacaggagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAACAtt < 2:314881‑M1/33‑1 (MQ=255) ttgtgatCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATCGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgt > 2:333054‑M2/3‑115 (MQ=255) tctcCAACTTATATTGGGGTCGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatg > 1:212248‑M2/1‑109 (MQ=255) gtcagtagctgaacaggagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCcagatat < 1:242356‑M1/43‑4 (MQ=255) ctcAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttcttgatagtgttttatgt < 1:419726‑M2/143‑36 (MQ=255) tcAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgtt < 1:82293‑M2/143‑37 (MQ=255) tatTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtcatgactccaacttattgatagtgttttatgttcagataatg < 2:471659‑M2/143‑46 (MQ=255) aacaggagcgacagctgatagaaacagaatccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCata > 2:67324‑M1/90‑143 (MQ=255) ggggTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccg > 1:484469‑M2/1‑94 (MQ=255) aggagggacggctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAg > 2:432486‑M1/87‑143 (MQ=255) gagggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGcc < 1:23632‑M1/59‑1 (MQ=255) ggacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTa < 1:79715‑M1/62‑1 (MQ=255) gacagctgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTAt > 1:132199‑M1/81‑143 (MQ=255) tgttgAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttg > 2:13727‑M2/1‑85 (MQ=255) gctgatagaatcagatgctactggagcatctcaaaaataccattatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTac > 1:395303‑M1/77‑143 (MQ=255) gctgatagaaacagaagccactggagcaactcaaaaacaccagcagacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTac > 1:102127‑M1/77‑143 (MQ=255) ttgAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtc < 1:125726‑M2/143‑61 (MQ=255) tgatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATACATATCTTTTCATAAAATTAGCCAGAAAGGACGCGCCATCTCGCCCTAATTacac < 2:148713‑M1/69‑1 (MQ=255) gatagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACAcc < 2:284671‑M1/70‑1 (MQ=255) atagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCg > 2:309061‑M1/73‑143 (MQ=255) aGGTAATAATAGAGACTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatg > 2:50075‑M2/1‑80 (MQ=255) aGGTAATAATAGAGAATTAAATTCAGTTGTGGAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatg > 1:238700‑M2/1‑80 (MQ=255) tagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTCTTTACACCga < 1:323447‑M1/72‑1 (MQ=255) tagaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCga > 1:508889‑M1/72‑143 (MQ=255) ggtttttatggagccttAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatgc > 2:177126‑M2/8‑79 (MQ=255) gctaattataGAGCTTTAAATTCAGTTGTTATCTTGCTAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTTTGCCGggtaatgattccaatttattgatagtgttttatgttcagataatgcccgatgactttgtcatgc > 2:118065‑M2/3‑79 (MQ=255) agaaacagaagccactggagcacctcaaaaacaccagcatacactaaatcagtaagtgggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCgat > 1:299442‑M1/71‑143 (MQ=255) gaaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACcgatc < 1:96339‑M1/74‑2 (MQ=255) aaacagaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCgatga < 1:490095‑M1/75‑1 (MQ=255) taataGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatggctttgtcatgcagctc > 1:370316‑M2/1‑74 (MQ=255) ataGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatgcagctcca > 1:272368‑M2/1‑72 (MQ=255) gaagccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCg > 1:128949‑M1/64‑143 (MQ=255) ccactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGCTGATTTCgcagc < 2:72070‑M1/84‑1 (MQ=255) cactggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCgcagca > 1:55615‑M1/59‑143 (MQ=255) actggagcacctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCAc < 1:53001‑M1/86‑1 (MQ=255) tAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatgcagctccaccgattttg > 1:313908‑M2/1‑63 (MQ=255) ctcaaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGTAGCACGTGAGGTTaa < 2:331963‑M1/96‑1 (MQ=255) caaaaacaccatcatacactaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGAGGCGGCATATAGCGCTATTTACACCGATGATTTCGCAGCACGTGAGGTTaaaa < 1:81362‑M1/98‑1 (MQ=255) aaacaccatcatacactaaatcagtaagttggcagcaccaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAaacgt < 2:122782‑M1/101‑3 (MQ=255) acactaaatcagtaagttggcagcatcaccTTGTGCTGCCAATAAATATCTTTTCATATAATTATCCAGAATTTACGCTGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGt > 1:467242‑M1/31‑143 (MQ=255) actaaatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTca < 1:269031‑M1/115‑1 (MQ=255) aatcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATACAATAAGCCAGAAAAGACGCGGCATTTAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACAtt < 1:384226‑M1/119‑1 (MQ=255) tcagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACAtttt < 1:42864‑M1/121‑1 (MQ=255) gAATTCAAAATTGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatgcagctccaccgattttgagaacgacagcgacttccgtcccagccgtgcca > 1:301973‑M2/1‑30 (MQ=255) cagtaagttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTAGACCGATGATGTCTCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTa < 1:97058‑M1/122‑1 (MQ=255) taggttggcagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTATgg > 1:368164‑M1/19‑143 (MQ=255) tCAAAATTTGTCTTTATTTTGTGCCGattaattatcccaatttatttgtagtgttttattttcagataatgcccgatgactttttcatgcagctccaccgattttgagaacgacagcgacttccgtcccagccgtgccaggtg > 2:133625‑M2/1‑26 (MQ=255) agtttgcagcatcaccGTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGTAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTATgggg > 2:181206‑M1/17‑143 (MQ=255) agttggcagcatccccTTGTGCCGCCAATAAATATCTGTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAACACGTGAGGTTAAAACTTCCTAATTCATGTCACATTTTATgggg > 2:210553‑M1/17‑143 (MQ=255) ttGTTCTTTATTTTGTGCCGggtaatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatgcagctccaccgattttgagaacgacagcgacttccgtcccagccgtgccaggtgctgcct > 1:316756‑M2/1‑20 (MQ=255) cagcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCGATTTACACCGATGATTTCGCAGCGCGTGAGAGTAAATCTTCCTGATTCATGTCAGAgtttattgggtgacta < 2:67101‑M1/133‑7 (MQ=255) agcatcaccTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGACTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGCCCCatcttatggggcgaccat < 2:117311‑M1/134‑8 (MQ=255) tCTTTATTTTGTGCCGgttaatgactccaacttattgatagtgttttatgttcagatcatgcccgatgactttgtcatgcagctccaccgattttgagaacgacagcgacttccgtcccagccgtgccaggtgctgcctcaga > 2:136907‑M2/1‑16 (MQ=255) gcatcaccGTGCGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTATGGGGAGATTATc > 1:412635‑M1/9‑143 (MQ=255) tttATTTTGTGCCGggtaatgactccaacttatggatagtgttttatgttcagataaggcccgatgactttgtcatgcagctccaccgattttgagaacgacagcgacttccggcccagccgtgccaggggctgcctcagagt < 1:370379‑M2/143‑130 (MQ=255) gttttgGGCCGggtagtgactccaacttattgatagcgtgttatgttcagataatgcccgatgactttgtcatgcagctccaccgattttgagaacgacagcgacttccgtcccagccgtgccaggtgctgcctcagattcag > 2:201444‑M2/2‑11 (MQ=255) accTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGCAAAGACGCGGCATATAGCCCTATTTACACCTATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTATGGGGAGATTATCGTAgg > 2:514860‑M1/4‑143 (MQ=255) aTTTTGTGCCGggttatgactccaacttattgatagtgttttatgttcagataatgcccgatgactttgtcatgcagctccaccgagtttgagaacgacagcgacttccgtcccagtcgtgcctggtgctgcctcagattcag > 2:28598‑M2/1‑11 (MQ=255) | ATGTTGTTCAGAATTTTAAGTGCTTCGCTCATTGTAGTAATCTCAAACTTATATTGGGGTGGTTTGTTGAGGTAATAATAGAGCCTTAAATTCAGTTGTGCAATAGCCAGGAATGTAAGGAATTCAAAATTGTTCTTTATTTTGTGCCGCCAATAAATATCTTTTCATAAAATTAGCCAGAAAAGACGCGGCATATAGCCCTATTTACACCGATGATTTCGCAGCACGTGAGGTTAAAACTTCCTGATTCATGTCACATTTTATGGGGAGATTATCGTAGG > NC_000913/1292891‑1293171 |
Alignment Legend |
---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 12 ≤ ATCG/ATCG < 13 ≤ ATCG/ATCG < 27 ≤ ATCG/ATCG < 41 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |
Reads not counted as support for junction |
read_name Not counted due to insufficient overlap past the breakpoint. |
read_name Not counted due to not crossing MOB target site duplication. |